Alzheimer's Disease and Related Disorders Annual 5 by Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings

By Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings

This quantity serves as a growth record on state of the art learn within the box of Alzheimer's disorder and different kinds of dementia, yet with an emphasis on subject matters which are appropriate to scientific perform. during this newest installment, Serge Gauthier, Philip Scheltens and Jeffrey Cummings conceal a few of the rising remedies for Alzheimer's sickness, together with statins, GAG minetics, and immunotherapy, in addition to using hormonal treatment and unusual anti-psychotic brokers within the remedy of alternative comparable dementias. Chapters also will summarize the present figuring out of the pathophysiology of light cognitive impairment in addition to learn into tau pathologies.

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When there is doubt about the diagnosis AD, with non-conclusive MRI or neuropsychological findings. 2. In patients with early-onset dementias (disease onset before 65 years old), as the differential diagnosis here is wider and more complicated; in particular, the differentiation of EAD from FTD is relevant. 3. In patients suspected for CJD, in combination with CSF 14-3-3 protein, MRI scan, and EEG. e. MRI parameters and/or neuropsychologic examinations. Investigate the diagnostic value of the biomarkers in primary and secondary referral settings, preferably with neuropathologic or prolonged clinical follow-up.

Qizilbash N, ed. Evidence-based Dementia Practice. Oxford: Blackwell Science, 2002. 34. Kanai M, Matsubara E, Isoe K, et al. Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer’s disease: a study in Japan. Ann Neurol 1998;44:17–26 35. Andreasen N, Minthon L, Davidsson P, et al. Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice. Arch Neurol 2001;58: 373–379. 36. Cutler RG, Kelly J, Storie K, et al.

Lancet Neurol 2003;2:605–613. 18. Hulstaert F, Blennow K, Ivanoiu A, et al. Improved discrimination of AD 02-Chapter 2 5 8/31/05 11:09 AM Page 30 30 ALZHEIMER’S DISEASE AND RELATED DISORDERS ANNUAL 19. 20. 21. 22. 23. 24. 25. 26. patients using beta-amyloid(1-42) and tau levels in CSF. Neurology 1999;52:1555–1562. Riemenschneider M, Wagenpfeil S, Diehl J, et al. Tau and Abeta42 protein in CSF of patients with frontotemporal degeneration. Neurology 2002;58:1622–1628. Sjogren M, Vanderstichele H, Agren H, et al.

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